OVI-123 (Cordycepin)

 

  • A Phase I/II clinical-stage drug
  • Active against TdT-positive leukemias
  • IP: Patent protection through 2014
    Next generation analogs: 2023
  • Status: Phase I/II clinical trial on-going at two sites in the US
  • Orphan Drug Designation obtained
  • Relevant Biomarker: TdT
  • Estimated Market Potential: >$350M

Cordycepin (3’-deoxyadenosine), a nucleoside analog, is OncoVista’s first clinical-stage development compound.

The compound was obtained through a merger with Aengus Pharmaceuticals which was completed in January 2006.

Cordycepin is a Phase I/II clinical stage drug candidate for treatment of refractory Acute Lymphoblastic Leukemia (ALL) patients who express the enzyme terminal deoxynucleotidyl transferase (TdT).

A Phase I/II clinical trial is currently enrolling and treating patients at two sites in the US: Dana Farber Cancer Institute (Boston MA) and the Cancer Treatment and Research Center (San Antonio TX)